About Pentacel® & Quadracel® Vaccines

Vaccine Antigens

Vaccination Schedule

For US Health Care Professionals
Pentacel® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate [Tetanus Toxoid Conjugate] Vaccine) logo and Quadracel® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine) logo
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For US Health Care Professionals
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To simplify the
DTaPa, IPVb, and Hibc
immunization series,
Count To
Four  And
Add One More
To simplify the DTaP, IPV, and Hib immunization series, count to four and add one more To simplify the DTaP, IPV, and Hib immunization series, count to four and add one more

a DTaP = Diphtheria, tetanus, and acellular pertussis;
b IPV = Inactivated poliovirus; c Hib = Haemophilus influenzae type b.

Pentacel® vaccine. The only Hib-containing DTaP-IPV combination vaccine with a 4-dose indication. DTaP-IPV/Hib vaccine. Doses at 2, 4, 6, and 15-18 months

The only Hib-containing DTaP-IPV
combination vaccine with a
4-dose indication1

Quadracel® vaccine. The same liquid DTaP-IPV component as in Pentacel vaccine. DTaP-IPV vaccine. Dose at 4-6 years.

The same liquid DTaP-IPV component as
in Pentacel vaccine1,2

Vaccine
DTaP-IPV/Hib
DTaP-IPV
Schedule
Doses at 2, 4, 6, and 15-18 months1
Dose at 4-6 years2
Little girl holding up 5 fingers

Continuity of using the same antigens
throughout the 5-dose series1-3

Continuity of using the same antigens throughout the 5-dose series. Pentacel vaccine (DTaP-IPV/Hib) for doses 1-4 with Quadracel vaccine (DTaP-IPV) for dose 5
Continuity of using the same antigens throughout the 5-dose series. Pentacel vaccine (DTaP-IPV/Hib) for doses 1-4 with Quadracel vaccine (DTaP-IPV) for dose 5
Continuity of using the same antigens throughout the 5-dose series. Pentacel vaccine (DTaP-IPV/Hib) for doses 1-4 with Quadracel vaccine (DTaP-IPV) for dose 5
Continuity of using the same antigens throughout the 5-dose series. Pentacel vaccine (DTaP-IPV/Hib) for doses 1-4 with Quadracel vaccine (DTaP-IPV) for dose 5
Continuity of using the same antigens throughout the 5-dose series. Pentacel vaccine (DTaP-IPV/Hib) for doses 1-4 with Quadracel vaccine (DTaP-IPV) for dose 5

Using Pentacel and Quadracel vaccines may help
SIMPLIFY THE VACCINATION SCHEDULE1,2,4

Recommended immunization schedule for children 6 years of age or younger4
Impact of Pentacel and Quadracel vaccines1,2,4
View without Pentacel and Quadracel vaccines4
Vaccine Age
Hepatitis B Hep B
Diphtheria, tetanus, pertussis DTaP
Inactivated poliovirus Polio
Haemophilus influenzae type b Hib
Rotavirus RV
Pneumococcal conjugate PCV
Influenza (2 doses for some) Flu (2 doses for some)
Measles, mumps, rubella MMR
Varicella Varicella
Hepatitis A Hep A
Meningococcal conjugate MCV
Pneumococcal polysaccharide PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
DTaP DTaP DTaP DTaP DTaP
IPV IPV IPV IPV
Hib Hib Hib Hib Hib
RV RV RV d
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRe MMR MMR
Varicella Varicella
Hep A (2-dose series) Hep A (2-dose series)
MCV
PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
Dose 1 Dose 2 Dose 3 Dose 4 Dose 5
Hib
RV RV RV d
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRe MMR MMR
Varicella Varicella
Hep A (2-dose series) Hep A (2-dose series)
MCV
PPSV

"...A combination vaccine generally is preferred..."
– Advisory Committee on Immunization Practices, 20174

Simplicity: Pentacel + Quadracel vaccines can streamline vaccine inventory management using just 2 combination products

Simplicity

Pentacel + Quadracel vaccines can streamline vaccine inventory management using just 2 combination products.1,2,4

Timeliness

Given at 2, 4, 6, and 15-18 months, Pentacel vaccine, as a combination vaccine, may increase timeliness and patient compliance.1

Timeliness: Given at 2, 4, 6, and 15-18 months, Pentacel vaccine, as a combination vaccine, may increase timeliness and patient compliance
Efficiency: Having fewer vaccines may allow for increased staff efficiency and prevention of administration errors

Efficiency

Having fewer vaccines may allow for increased staff efficiency and prevention of administration errors.

Count to four and add one more
Provide CDCf-recommended DTaP, IPV, and Hib protection with Pentacel vaccine + Quadracel vaccine1,2,4

Immunity

Pentacel and Quadracel vaccines are proven to be effective in inducing immune responses similar to separately administered vaccines.1,2

Immunity: Pentacel and Quadracel vaccines are proven to be effective in inducing immune responses similar to separately administered vaccines
Continuity: Quadracel vaccine, indicated for children 4-6 years of age, is the same liquid DTaP-IPV component as in Pentacel vaccine and allows for continuity of using the same antigens for the essential fifth dose

Continuity

Quadracel vaccine, indicated for children 4-6 years of age, is the same liquid DTaP-IPV component as in Pentacel vaccine and allows for continuity of using the same antigens for the essential fifth dose.1-3

Fever

The rates of fever for Pentacel and Quadracel vaccines were comparable to individually administered vaccines.1,2

Fever: The rates of fever for Pentacel and Quadracel vaccines were comparable to individually administered vaccines
f CDC = Centers for Disease Control and Prevention.

Important Safety Information

Safety information for pentacel and quadracel vaccines

Contraindications to vaccination with Pentacel or Quadracel vaccine include: severe allergic reaction (eg, anaphylaxis) to any ingredient of the