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For US Health Care Professionals

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Pentacel® mascot dressed as a doctor

HELPING PROTECT KIDS IS A FULL-TIME JOB
AND PENTACEL IS UP TO THE TASK

Let's work together and help protect kids against potentially deadly diseases with the DTaP-IPV/Hib vaccine.1

INDICATION FOR PENTACEL AND QUADRACEL

Pentacel is indicated for active immunization against diphtheria, tetanus, pertussis, poliomyelitis, and invasive disease due to H influenzae type b. Pentacel is approved for use as a 4-dose series in children 6 weeks through 4 years of age (prior to fifth birthday).

Quadracel is indicated for active immunization against diphtheria, tetanus, pertussis, and poliomyelitis. A single dose of Quadracel is approved as a fifth dose in the diphtheria, tetanus, pertussis (DTaP) vaccination series, and as a fourth or fifth dose in the inactivated poliovirus (IPV) vaccination series, in children 4 through 6 years of age whose previous DTaP vaccine doses have been with Pentacel and/or DAPTACEL® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed), and/or VAXELIS® (Diphtheria and Tetanus Toxoids and Acellular Pertussis, Inactivated Poliovirus, Haemophilus b Conjugate and Hepatitis B Vaccine).

IT TAKES TWO:
PENTACEL & QUADRACEL

Start your primary DTaP immunization series in children 6 weeks through 4 years of age (prior to 5th birthday) with 4 doses of Pentacel, the only DTaP-IPV-Hib combination.1

Finish the DTaP series with Quadracel as the 5th dose in children 4 through 6 years of age.2

Pentacel® logo

The only Hib-containing DTaP-IPV
combination vaccine with a
4-dose indication1

Quadracel® logo

The same liquid DTaP-IPV component as
in Pentacel1,2

Antigens

DTaP-IPV/Hib1

DTaP-IPV2

Schedule

Doses at 2, 4, 6, and 15-18 months1,3

A dose at 4-6 years2,3

Young boy with his hands on his hips

CONTINUITY OF ANTIGENS
across the entire childhood DTaP and IPV series1-5

1st Pentacel® shot at 2 months
2nd Pentacel® shot at 4 months
3rd Pentacel® shot at 6 months
4th Pentacel® shot at 15-18 months
bracket under Pentacel blue blocks
5th Quadracel® shot at 4-6 years
bracket under Quadracel pink block

A WAY TO COMPLETE THE DTaP
SERIES WITH PENTACEL

Even if you didn't use Pentacel for the first 3 doses, you can use it for the fourth dose of the DTaP series containing the same pertussis antigens as in Pentacel.1*

*Data are not available on the safety and effectiveness of using mixed sequences of Pentacel and DTaP vaccine from different manufacturers.

Pentacel and Quadracel may simplify vaccine administration by supporting
A VACCINATION SCHEDULE
WITH FEWER INJECTIONS1-4
compared to single-entity alternatives

Centers for Disease Control and Prevention schedule through 6 years of age3
IMPACT OF PENTACEL AND QUADRACEL1-3
POTENTIAL SHOT
SAVINGS1-3
WITHOUT PENTACEL AND QUADRACEL1-3
Vaccine Down arrow Age Down arrow
Hepatitis B Hep B
Diphtheria, tetanus, pertussis DTaP
Inactivated poliovirus Polio
Haemophilus influenzae type b Hib
Rotavirus RV
Pneumococcal conjugate PCV
Influenza (2 doses for some) Flu (2 doses for some)
Measles, mumps, rubella MMR
Varicella Varicella
Hepatitis A Hep A
Meningococcal MenACWY
Pneumococcal polysaccharide PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
9
Months
9
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
DTaP DTaP DTaP DTaP DTaP
IPV IPV IPV IPV
Hib Hib Hib Hib Hib
RV RV RVb
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRc MMR MMR
Varicella Varicella
Hep A Hep A (2-dose series)
MenACWY
PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
9
Months
9
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
Hib
RV RV RVb
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRc MMR MMR
Varicella Varicella
Hep A Hep A (2-dose series)
MenACWY
PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
9
Months
9
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
Hib
RV RV RVb
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRc MMR MMR
Varicella Varicella
Hep A Hep A (2-dose series)
MenACWY
PPSV

“USE COMBINATION VACCINES
INSTEAD OF SEPARATE INJECTIONS
WHEN APPROPRIATE.”
– Advisory Committee on Immunization Practices, 20213

See real-world evidence

View the Pentacel pivotal study on DTaP combination use and adherence.

View Now

Globe icon
Two vaccine vials

Help minimize the
number of injections

Pentacel & Quadracel allow you to use only 2 products across the entire childhood series for DTaP, IPV, and Hib.1-4

Help improve timeliness of vaccination coverage

Combination vaccines may help increase timeliness of vaccination administration and coverage.4,6,7

Illustration of a woman
Increasing bar graph with upward arrows

Help streamline inventory, billing, and administration prep time4

COMPLETE THE DTaP, IPV, AND Hib SERIES
FROM START TO FINISH
Provide CDC-recommended DTaP, IPV, and Hib immunizations
with Pentacel & Quadracel1-3

Thermometer icon

Most common
adverse reactions

The most common local and systemic adverse reactions to Pentacel include erythema, swelling, and tenderness at the injection site; fever; fussiness; and abnormal crying. The most common local and systemic adverse reactions to Quadracel include pain, erythema, and edema at the injection site; myalgia, malaise, and headache.1,2

One less injection

By using Quadracel, a combination booster dose, you can complete the DTaP and IPV immunization series with one less injection and fewer vaccines to store in your refrigerator compared to single-entity alternatives.2,3

Down arrow
A vaccine bottle with a label displaying 5

Antigen continuity

Using Quadracel, you can have continuity of DTaP and IPV antigens across the 5-dose series1-3,5

Important Safety Information for Pentacel and Quadracel

Contraindications to vaccination with Pentacel or Quadracel vaccine include: a severe allergic reaction (e.g., anaphylaxis) to any ingredient of the vaccine, or following any other diphtheria toxoid-, tetanus toxoid-, pertussis antigen-containing vaccine, inactivated poliovirus vaccine, or Haemophilus influenzae type b vaccine (Pentacel only); encephalopathy within 7 days after a previous dose of a pertussis antigen-containing vaccine with no other identifiable cause; or a progressive neurologic disorder.

Please see full Prescribing Information for Pentacel.
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Please see full Prescribing Information for Pentacel.
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Please see full Prescribing Information for Pentacel.
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