For US Health Care Professionals
a DTaP = Diphtheria, tetanus, and acellular pertussis;
b IPV = Inactivated poliovirus; c Hib = Haemophilus influenzae type b.
The only Hib-containing DTaP-IPV
combination vaccine with a
4-dose indication1
The same liquid DTaP-IPV component as
in Pentacel vaccine1,2
Age
Birth Birth |
1 Month 1 Mo. |
2 Months 2 Mos. |
4 Months 4 Mos. |
6 Months 6 Mos. |
12 Months 12 Mos. |
15 Months 15 Mos. |
18 Months 18 Mos. |
19-23 Months 19-23 Mos. |
2-3 Years 2-3 Yrs. |
4-6 Years 4-6 Yrs. |
|---|---|---|---|---|---|---|---|---|---|---|
| Hep B | Hep B | Hep B | ||||||||
| DTaP | DTaP | DTaP | DTaP | DTaP | ||||||
| IPV | IPV | IPV | IPV | |||||||
| Hib | Hib | Hib | Hib | Hib | ||||||
| RV | RV | RVe | ||||||||
| PCV | PCV | PCV | PCV | PCV | ||||||
| Influenza (yearly) | ||||||||||
| MMRf | MMR | MMR | ||||||||
| Varicella | Varicella | |||||||||
| Hep A (2-dose series) | Hep A (2-dose series) | |||||||||
| MCV | ||||||||||
| PPSV | ||||||||||
Birth Birth |
1 Month 1 Mo. |
2 Months 2 Mos. |
4 Months 4 Mos. |
6 Months 6 Mos. |
12 Months 12 Mos. |
15 Months 15 Mos. |
18 Months 18 Mos. |
19-23 Months 19-23 Mos. |
2-3 Years 2-3 Yrs. |
4-6 Years 4-6 Yrs. |
|---|---|---|---|---|---|---|---|---|---|---|
| Hep B | Hep B | Hep B | ||||||||
| Dose 1 | Dose 2 | Dose 3 | Dose 4 | Dose 5 | ||||||
|
|
|
|
||||||||
| Hib | ||||||||||
| RV | RV | RVe | ||||||||
| PCV | PCV | PCV | PCV | PCV | ||||||
| Influenza (yearly) | ||||||||||
| MMRf | MMR | MMR | ||||||||
| Varicella | Varicella | |||||||||
| Hep A (2-dose series) | Hep A (2-dose series) | |||||||||
| MCV | ||||||||||
| PPSV | ||||||||||
Pentacel + Quadracel vaccines can help streamline vaccine inventory management using just 2 combination products.1,2,4
Given at 2, 4, 6, and 15-18 months, Pentacel vaccine, as a combination vaccine, may help increase timeliness and patient compliance.1,5,6
Having fewer vaccines may help allow for increased staff efficiency and prevention of administration errors.
Pentacel and Quadracel vaccines are proven to be effective in inducing immune responses similar to separately administered vaccines.1,2
Quadracel vaccine, indicated for children 4-6 years of age, is the same liquid DTaP-IPV component as in Pentacel vaccine and allows for continuity of using the same antigens for the essential fifth dose.1-3
The rates of fever for Pentacel and Quadracel vaccines were comparable to individually administered vaccines.1,2
Contraindications to vaccination with Pentacel or Quadracel vaccine include: a severe allergic reaction (eg, anaphylaxis) to any ingredient of the
Contraindications to vaccination with Pentacel or Quadracel vaccine include: a severe allergic reaction (eg, anaphylaxis) to any ingredient of the vaccine, or following any other diphtheria toxoid-, tetanus toxoid-, pertussis antigen-containing vaccine, inactivated poliovirus vaccine, or Haemophilus influenzae type b vaccine (Pentacel vaccine only); encephalopathy within 7 days after a previous dose of a pertussis antigen-containing vaccine with no other identifiable cause; or a progressive neurologic disorder.
Carefully consider benefits and risks before administering Pentacel or Quadracel vaccine to persons with a history of: fever ≥105°F, hypotonic-hyporesponsive episode (HHE), or persistent, inconsolable crying lasting ≥3 hours within 48 hours after a previous pertussis antigen-containing vaccine; seizures within 3 days after a previous pertussis antigen-containing vaccine; Guillain-Barré syndrome occurring within 6 weeks following receipt of a prior vaccine containing tetanus toxoid; or adverse events after a previous dose of Pentacel or Quadracel vaccine or receipt of any other tetanus toxoid-, diphtheria toxoid-, or pertussis antigen-containing vaccine.
For infants and children with a history of previous seizures, an antipyretic may be administered (in the dosage recommended in its prescribing information) at the time of vaccination with Pentacel vaccine and for the next 24 hours.
Apnea following intramuscular vaccination has been observed in some infants born prematurely.
The most common local and systemic adverse reactions to Pentacel vaccine include erythema, swelling, and tenderness at the injection site; fever, fussiness, and abnormal crying. The most common local and systemic adverse reactions to Quadracel vaccine include pain, erythema, and edema at the injection site; myalgia, malaise, and headache. Other adverse reactions may occur.
Vaccination with Pentacel or Quadracel vaccine may not protect all individuals.
Pentacel vaccine is indicated for active immunization against diphtheria, tetanus, pertussis, poliomyelitis, and invasive disease due to H influenzae type b. Pentacel vaccine is approved for use as a 4-dose series in children 6 weeks through 4 years of age (prior to fifth birthday).
Quadracel vaccine is indicated for active immunization against diphtheria, tetanus, pertussis, and poliomyelitis. A single dose of Quadracel vaccine is approved for use in children 4 through 6 years of age as a fifth dose in the diphtheria, tetanus, pertussis vaccination (DTaP) series, and as a fourth or fifth dose in the inactivated poliovirus vaccination (IPV) series, in children who have received 4 doses of Pentacel vaccine and/or DAPTACEL® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed).
Before administration, please see the full Prescribing Information for Pentacel or Quadracel vaccine.
CPT®g Code for Pentacel vaccine: 90698
CPT Code for Quadracel vaccine: 90696
g CPT (Current Procedural Terminology) is a registered trademark of the American Medical Association.
Pentacel vaccine is manufactured by Sanofi Pasteur Limited and Sanofi Pasteur SA and distributed by Sanofi Pasteur Inc.
Quadracel vaccine is manufactured by Sanofi Pasteur Limited and distributed by Sanofi Pasteur Inc.
![Pentacel® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate [Tetanus Toxoid Conjugate] Vaccine) logo and Quadracel® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine) logo](resources/images/logos/pq_logo.png "Pentacel® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate [Tetanus Toxoid Conjugate] Vaccine) logo and Quadracel® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine) logo"){kind=logo}
