About Pentacel® & Quadracel® Vaccines

Vaccine Antigens

Vaccination Schedule

For US Health Care Professionals
Pentacel® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate [Tetanus Toxoid Conjugate] Vaccine) logo and Quadracel® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine) logo
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For US Health Care Professionals
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To help simplify the
DTaPa, IPVb, and Hibc series
with fewer injections,1-3
Count To
Four  And
Add One More
Baby with blocks numbered 1 to 5 Baby with blocks numbered 1 to 5

a DTaP = Diphtheria, tetanus, and acellular pertussis;
b IPV = Inactivated poliovirus; c Hib = Haemophilus influenzae type b.

INDICATION FOR PENTACEL AND QUADRACEL

Pentacel vaccine is indicated for active immunization against diphtheria, tetanus, pertussis, poliomyelitis, and invasive disease due to H influenzae type b. Pentacel vaccine is approved for use as a 4-dose series in children 6 weeks through 4 years of age (prior to fifth birthday).

Quadracel vaccine is indicated for active immunization against diphtheria, tetanus, pertussis, and poliomyelitis. A single dose of Quadracel vaccine is approved for use in children 4 through 6 years of age as a fifth dose in the diphtheria, tetanus, pertussis vaccination (DTaP) series, and as a fourth or fifth dose in the inactivated poliovirus vaccination (IPV) series, in children who have received 4 doses of Pentacel vaccine and/or DAPTACEL® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed).

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Pentacel icon

The only Hib-containing DTaP-IPV
combination vaccine with a
4-dose indication1

Quadracel icon

The same liquid DTaP-IPV component as
in Pentacel vaccine1,2

Vaccine
DTaP-IPV/Hib1
DTaP-IPV2
Schedule
Doses at 2, 4, 6, and 15-18 months1
Dose at 4-6 years2
Young girl holding up 5 fingers

Continuity of antigens
across the entire childhood series1,2,4

Pentacel blue block number 1
Pentacel blue block number 2
Pentacel blue block number 3
Pentacel blue block number 4
Quadracel purple block number 5
Pentacel icon
Quadracel icon

The simplified Pentacel and Quadracel immunization series incorporates
A VACCINATION SCHEDULE WITH FEWER INJECTIONS1-3
compared to single dose alternatives

CDCd schedule through 6 years of age3
Impact of Pentacel and Quadracel1-3
Potential Shot Savings1-3
Without Pentacel and Quadracel1-3
Vaccine Age
Hepatitis B Hep B
Diphtheria, tetanus, pertussis DTaP
Inactivated poliovirus Polio
Haemophilus influenzae type b Hib
Rotavirus RV
Pneumococcal conjugate PCV
Influenza (2 doses for some) Flu (2 doses for some)
Measles, mumps, rubella MMR
Varicella Varicella
Hepatitis A Hep A
Meningococcal MenACWY
Pneumococcal polysaccharide PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
DTaP DTaP DTaP DTaP DTaP
IPV IPV IPV IPV
Hib Hib Hib Hib Hib
RV RV RVe
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRf MMR MMR
Varicella Varicella
Hep A (2-dose series) Hep A (2-dose series)
MenACWY
PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
Dose 1 Dose 2 Dose 3 Dose 4 Dose 5
Hib
RV RV RVe
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRf MMR MMR
Varicella Varicella
Hep A (2-dose series) Hep A (2-dose series)
MenACWY
PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
Dose 1 Dose 2 Dose 3 Dose 4 Dose 5
Hib
RV RV RVe
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRf MMR MMR
Varicella Varicella
Hep A (2-dose series) Hep A (2-dose series)
MenACWY
PPSV

"Use combination vaccines instead of separate injections when appropriate."
– Advisory Committee on Immunization Practices, 20195
By using these two combination vaccines as directed, your office could:

Blue and purple pill bottle icons

Help minimize the number of injections

Pentacel + Quadracel vaccines allow you to use only 2 products across the entire childhood series.1-3

Help improve timeliness and vaccination compliance

Given at 2, 4, 6, and 15-18 months, Pentacel vaccine, as a combination vaccine, may help increase timeliness of vaccination and patient compliance.6,7

Doctor icon with check mark
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Help streamline inventory, billing, and administration prep time

Count to four and add one more
Provide CDC-recommended DTaP, IPV, and Hib protection with Pentacel vaccine + Quadracel vaccine1-3

Efficacy

In a pivotal trial among children 4-6 years of age, Quadracel vaccine induced antibody responses non-inferior to separately administered vaccines, DAPTACEL® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) and IPOL® (Poliovirus Vaccine Inactivated) vaccines2

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Most common adverse reactions

The most common local and systemic adverse reactions to Pentacel vaccine, which were comparable to those seen after DAPTACEL and IPOL, include erythema, swelling, and tenderness at the injection site; fever, fussiness, and abnormal crying. The most common local and systemic adverse reactions to Quadracel vaccine, which were comparable to those seen after DAPTACEL and IPOL, include pain, erythema, and edema at the injection site; myalgia, malaise, and headache.1,2

Reduced injections

By using Quadracel vaccine, a combination booster dose, you can complete the series and potentially reduce the number of injections needed and the number of vaccines in your refrigerator2,3

Downward arrow
Bottle icon for 5th dose

Continuity

Using Pentacel and Quadracel vaccines together, you can have continuity of DTaP and IPV antigens across the 5-dose series1,2,4

Important Safety Information for Pentacel and Quadracel

Contraindications to vaccination with Pentacel or Quadracel vaccine include: a severe allergic reaction (eg, anaphylaxis) to any ingredient of the vaccine, or following any other diphtheria toxoid-, tetanus toxoid-, pertussis antigen-containing vaccine, inactivated poliovirus vaccine, or

x

Prescribing Information for Pentacel (49281-0510-05 and 49281-0511-05) and Quadracel Vaccines