For US Health Care Professionals

Please see full Important Safety Information for Pentacel and Quadracel below.
Please see full Prescribing Information for Pentacel and Quadracel (49281-564-10/15 and 49281-562-10).
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For US Health Care Professionals

Please see full Important Safety Information for Pentacel and Quadracel below.
Please see full Prescribing Information for Pentacel and Quadracel (49281-564-10/15 and 49281-562-10).
Medical Information
Order Now
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Pentacel® mascot dressed as a doctor

HELPING PROTECT KIDS IS A FULL-TIME JOB
AND PENTACEL IS UP TO THE TASK

Let's work together and help protect kids against potentially deadly diseases with the DTaP-IPV/Hib vaccine.1

INDICATION FOR PENTACEL AND QUADRACEL

Pentacel is indicated for active immunization against diphtheria, tetanus, pertussis, poliomyelitis, and invasive disease due to H influenzae type b. Pentacel is approved for use as a 4-dose series in children 6 weeks through 4 years of age (prior to fifth birthday).

Quadracel is indicated for active immunization against diphtheria, tetanus, pertussis, and poliomyelitis. A single dose of Quadracel is approved as a fifth dose in the diphtheria, tetanus, pertussis (DTaP) vaccination series, and as a fourth or fifth dose in the inactivated poliovirus (IPV) vaccination series, in children 4 through 6 years of age whose previous DTaP vaccine doses have been with Pentacel and/or DAPTACEL® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed), and/or VAXELIS® (Diphtheria and Tetanus Toxoids and Acellular Pertussis, Inactivated Poliovirus, Haemophilus b Conjugate and Hepatitis B Vaccine).

IT TAKES TWO:
PENTACEL & QUADRACEL

Start your primary DTaP immunization series in children 6 weeks through 4 years of age (prior to 5th birthday) with 4 doses of Pentacel, the only DTaP-IPV-Hib combination.1

Finish the DTaP series with Quadracel as the 5th dose in children 4 through 6 years of age.2

Pentacel® logo

The only Hib-containing DTaP-IPV
combination vaccine with a
4-dose indication1

Quadracel® logo

The same liquid DTaP-IPV component as
in Pentacel1,2

Antigens

DTaP-IPV/Hib1

DTaP-IPV2

Schedule

Doses at 2, 4, 6, and 15-18 months1,3

A dose at 4-6 years2,3

Young boy with his hands on his hips

CONTINUITY OF ANTIGENS
across the entire childhood DTaP and IPV series1-5

1st Pentacel® shot at 2 months
2nd Pentacel® shot at 4 months
3rd Pentacel® shot at 6 months
4th Pentacel® shot at 15-18 months
bracket under Pentacel blue blocks
5th Quadracel® shot at 4-6 years
bracket under Quadracel pink block

A WAY TO COMPLETE THE DTaP
SERIES WITH PENTACEL

Even if you didn't use Pentacel for the first 3 doses, you can use it for the fourth dose of the DTaP series containing the same pertussis antigens as in Pentacel.1*

*Data are not available on the safety and effectiveness of using mixed sequences of Pentacel and DTaP vaccine from different manufacturers.

TODDLERS KNOW THE DARNDEST THINGS
ABOUT VACCINES

Our cast is tiny but very chatty. Hear what they have to say about Pentacel.

Pentacel and Quadracel may simplify vaccine administration by supporting
A VACCINATION SCHEDULE
WITH FEWER INJECTIONS1-4
compared to single-entity alternatives

Centers for Disease Control and Prevention schedule through 6 years of age3
IMPACT OF PENTACEL AND QUADRACEL1-3
POTENTIAL SHOT
SAVINGS1-3
WITHOUT PENTACEL AND QUADRACEL1-3
Vaccine Down arrow Age Down arrow
Hepatitis B Hep B
Diphtheria, tetanus, pertussis DTaP
Inactivated poliovirus Polio
Haemophilus influenzae type b Hib
Rotavirus RV
Pneumococcal conjugate PCV
Influenza (2 doses for some) Flu (2 doses for some)
Measles, mumps, rubella MMR
Varicella Varicella
Hepatitis A Hep A
Meningococcal MenACWY
Pneumococcal polysaccharide PPSV

Birth Birth		 1
Month 1
Mo.		 2
Months 2
Mos.		 4
Months 4
Mos.		 6
Months 6
Mos.		 9
Months 9
Mos.		 12
Months 12
Mos.		 15
Months 15
Mos.		 18
Months 18
Mos.		 19-23
Months 19-23
Mos.		 2-3
Years 2-3
Yrs.		 4-6
Years 4-6
Yrs.
Hep B Hep B Hep B
DTaP DTaP DTaP DTaP DTaP
IPV IPV IPV IPV
Hib Hib Hib Hib Hib
RV RV RVb
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRc MMR MMR
Varicella Varicella
Hep A Hep A (2-dose series)
MenACWY
PPSV

Birth Birth		 1
Month 1
Mo.		 2
Months 2
Mos.		 4
Months 4
Mos.		 6
Months 6
Mos.		 9
Months 9
Mos.		 12
Months 12
Mos.		 15
Months 15
Mos.		 18
Months 18
Mos.		 19-23
Months 19-23
Mos.		 2-3
Years 2-3
Yrs.		 4-6
Years 4-6
Yrs.
Hep B Hep B Hep B
Hib
RV RV RVb
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRc MMR MMR
Varicella Varicella
Hep A Hep A (2-dose series)
MenACWY
PPSV

Birth Birth		 1
Month 1
Mo.		 2
Months 2
Mos.		 4
Months 4
Mos.		 6
Months 6
Mos.		 9
Months 9
Mos.		 12
Months 12
Mos.		 15
Months 15
Mos.		 18
Months 18
Mos.		 19-23
Months 19-23
Mos.		 2-3
Years 2-3
Yrs.		 4-6
Years 4-6
Yrs.
Hep B Hep B Hep B
Hib
RV RV RVb
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRc MMR MMR
Varicella Varicella
Hep A Hep A (2-dose series)
MenACWY
PPSV

Range of recommended ages for all children

Range of recommended ages for certain high-risk groups

Adapted from: Recommended child and adolescent immunization schedule for ages 18 years or younger, United States, 2022.

aEven if you didn't use Pentacel for the first 3 doses, you can use it for the fourth dose of the DTaP series containing the same pertussis antigens as in Pentacel.1,d

Vaccination schedules may vary based on patients’ overall health status.3

bDepending on the type of vaccine used, a 3rd dose may be required.

cFor certain high-risk groups, a dose at 6-11 months of age is recommended.

dData are not available on the safety and effectiveness of using mixed sequences of Pentacel and DTaP vaccine from different manufacturers.

“USE COMBINATION VACCINES
INSTEAD OF SEPARATE INJECTIONS
WHEN APPROPRIATE.”
– Advisory Committee on Immunization Practices, 20213

See real-world evidence

View the Pentacel pivotal study on DTaP combination use and adherence.

View Now

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Two vaccine vials

Help minimize the
number of injections

Pentacel & Quadracel allow you to use only 2 products across the entire childhood series for DTaP, IPV, and Hib.1-4

Help improve timeliness of vaccination coverage

Combination vaccines may help increase timeliness of vaccination administration and coverage.4,6,7

Illustration of a woman
Increasing bar graph with upward arrows

Help streamline inventory, billing, and administration prep time4

COMPLETE THE DTaP, IPV, AND Hib SERIES
FROM START TO FINISH
Provide CDC-recommended DTaP, IPV, and Hib immunizations
with Pentacel & Quadracel1-3

Thermometer icon

Most common
adverse reactions

The most common local and systemic adverse reactions to Pentacel include erythema, swelling, and tenderness at the injection site; fever; fussiness; and abnormal crying. The most common local and systemic adverse reactions to Quadracel include pain, erythema, and edema at the injection site; myalgia, malaise, and headache.1,2

One less injection

By using Quadracel, a combination booster dose, you can complete the DTaP and IPV immunization series with one less injection and fewer vaccines to store in your refrigerator compared to single-entity alternatives.2,3

Down arrow
A vaccine bottle with a label displaying 5

Antigen continuity

Using Quadracel, you can have continuity of DTaP and IPV antigens across the 5-dose series1-3,5

Important Safety Information for Pentacel and Quadracel

Contraindications to vaccination with Pentacel or Quadracel vaccine include: a severe allergic reaction (e.g., anaphylaxis) to any ingredient of the vaccine, or following any other diphtheria toxoid-, tetanus toxoid-, pertussis antigen-containing vaccine, inactivated poliovirus vaccine, or Haemophilus influenzae type b vaccine (Pentacel only); encephalopathy within 7 days after a previous dose of a pertussis antigen-containing vaccine with no other identifiable cause; or a progressive neurologic disorder.

Important Safety Information for Pentacel and Quadracel

Contraindications to vaccination with Pentacel or Quadracel include: a severe allergic reaction (e.g., anaphylaxis) to any ingredient of the vaccine, or following any other diphtheria toxoid-, tetanus toxoid-, pertussis antigen-containing vaccine, inactivated poliovirus vaccine, or Haemophilus influenzae type b vaccine (Pentacel only); encephalopathy within 7 days after a previous dose of a pertussis antigen-containing vaccine with no other identifiable cause; or a progressive neurologic disorder.

Carefully consider benefits and risks before administering Pentacel or Quadracel to persons with a history of: fever ≥105°F, hypotonic-hyporesponsive episode, or persistent, inconsolable crying lasting ≥3 hours within 48 hours after a previous pertussis antigen-containing vaccine; seizures within 3 days after a previous pertussis antigen-containing vaccine; Guillain-Barré syndrome occurring within 6 weeks following receipt of a prior vaccine containing tetanus toxoid; or adverse events after a previous dose of Pentacel or Quadracel or receipt of any other tetanus toxoid-, diphtheria toxoid-, or pertussis antigen-containing vaccine.

For infants and children with a history of previous seizures, an antipyretic may be administered (in the dosage recommended in its prescribing information) at the time of vaccination with Pentacel and for the next 24 hours.

Apnea following intramuscular vaccination has been observed in some infants born prematurely.

Syncope (fainting) may occur in association with administration of injectable vaccines including Pentacel and Quadracel. Procedures should be in place to avoid injury from fainting.

The most common local and systemic adverse reactions to Pentacel include erythema, swelling, and tenderness at the injection site; fever, fussiness, and abnormal crying. The most common local and systemic adverse reactions to Quadracel include pain, erythema, and edema at the injection site; myalgia, malaise, and headache. Other adverse reactions may occur.

Vaccination with Pentacel or Quadracel may not protect all individuals.

Before administration, please see the full Prescribing Information for Pentacel and Quadracel (49281-564-10/15 and 49281-562-10).

CPT®e Code for Pentacel: 90698

CPT Code for Quadracel: 90696

Pentacel is manufactured by Sanofi Pasteur Limited and Sanofi Pasteur SA, and distributed by Sanofi Pasteur Inc.

Quadracel is manufactured by Sanofi Pasteur Limited and distributed by Sanofi Pasteur Inc.

AR = augmented reality; DTaP = diphtheria, tetanus, and acellular pertussis; IPV = inactivated poliovirus; Hib = Haemophilus influenzae type b.

eCPT (Current Procedural Terminology) is a registered trademark of the American Medical Association.

References:
  • Pentacel. Prescribing Information. NDC No. 49281-0511-05. Sanofi Pasteur Limited.
  • Quadracel. Prescribing Information. NDC No. 49281-564-10/15. Sanofi Pasteur Limited; Quadracel. Prescribing Information. NDC No. 49281-562-10. Sanofi Pasteur Limited.
  • Centers for Disease Control and Prevention (CDC). Recommended child and adolescent immunization schedule for ages 18 years or younger, United States, 2022. Accessed October 31, 2022. https://www.cdc.gov/vaccines/schedules/
    downloads/child/0-18yrs-child-combined-schedule.pdf
  • Kroger A, Bahta L, Hunter P. General best practice guidelines for immunization: best practices guidance of the Advisory Committee on Immunization Practices (ACIP). Centers for Disease Control and Prevention. March 15, 2022. Accessed October 31, 2022. https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/downloads/general-recs.pdf
  • Liang J, Wallace G, Mootrey G. Licensure of a diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine and guidance for use as a booster dose. MMWR. 2015;64(34):948-949.
  • Kalies H, Grote V, Verstraeten T, Hessel L, Schmitt HJ, von Kries R. The use of combination vaccines has improved timeliness of vaccination in children. Pediatr Infect Dis J. 2006;25(6):507-512.
  • Marshall GS, Happe LE, Lunacsek OE, et al. Use of combination vaccines is associated with improved coverage rates. Pediatr Infect Dis J. 2007;26(6):496-500.
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This site is intended for US Health Care Professionals.
© 2022 Sanofi Pasteur Inc.
Last Modified 11/2022
MAT-US-2006087-v5.0-10/2022
Please see full Prescribing Information for Pentacel.
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Please see full Prescribing Information for Pentacel.
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Please see full Prescribing Information for Pentacel.
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