About Pentacel® & Quadracel®

Vaccine Antigens

Vaccination Schedule

For US Health Care Professionals

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For US Health Care Professionals

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Start Strong, Finish Strong
Schedule for children from 2 months to 6 years For children at 2 months, 4 months, 6 months, 15-18 months and 4-6 years

Start your primary DTaP immunization series in children 6 weeks through 4 years of age (prior to 5th birthday) with 4 doses of Pentacel, the only DTaP-IPVb-Hibc combination. Finish the DTaP series with Quadracel as the 5th dose in children 4 through 6 years of age.1,2

Completing the series with Pentacel and Quadracel reduces the number of injections as compared with single-entity vaccines. By using Quadracel, it satisfies the ACIP’sd 5-dose DTaP recommendation with full antigen continuity.1-4

Completing the series with Pentacel and Quadracel reduces the number of injections as compared with single-entity vaccines. By using Quadracel, it satisfies the ACIP’sd 5-dose DTaP recommendation with full antigen continuity.1-4

INDICATION FOR PENTACEL AND QUADRACEL

Pentacel is indicated for active immunization against diphtheria, tetanus, pertussis, poliomyelitis, and invasive disease due to H influenzae type b. Pentacel is approved for use as a 4-dose series in children 6 weeks through 4 years of age (prior to fifth birthday).

Quadracel is indicated for active immunization against diphtheria, tetanus, pertussis, and poliomyelitis. A single dose of Quadracel is approved for use in children 4 through 6 years of age as a fifth dose in the diphtheria, tetanus, pertussis vaccination (DTaP) series, and as a fourth or fifth dose in the inactivated poliovirus vaccination (IPV) series, in children who have received 4 doses of Pentacel vaccine and/or DAPTACEL® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed).

It Takes Two:
Pentacel & Quadracel

Pentacel icon

The only Hib-containing DTaP-IPV
combination vaccine with a
4-dose indication1

Quadracel icon

The same liquid DTaP-IPV component as
in Pentacel1,2

Antigens

DTaP-IPV/Hib1

DTaP-IPV2

Schedule

Doses at 2, 4, 6, and 15-18 months1,3

A dose at 4-6 years2,3

Young boy with his hands on his hips

CONTINUITY OF ANTIGENS
across the entire childhood DTaP and IPV series1-3,5

Pentacel blue block number 1
Pentacel blue block number 2
Pentacel blue block number 3
Pentacel blue block number 4
bracket under Pentacel blue blocks
Pentacel icon
baby
Quadracel purple block number 5
bracket under Quadracel purple blocks
Quadracel icon

Pentacel and Quadracel may simplify vaccine administration by supporting
A VACCINATION SCHEDULE
WITH FEWER INJECTIONS1-4
compared to single-entity alternatives

Centers for Disease Control and Prevention schedule through 6 years of age3
IMPACT OF PENTACEL AND QUADRACEL1-3
POTENTIAL SHOT
SAVINGS1-3
WITHOUT PENTACEL AND QUADRACEL1-3
Vaccine Age
Hepatitis B Hep B
Diphtheria, tetanus, pertussis DTaP
Inactivated poliovirus Polio
Haemophilus influenzae type b Hib
Rotavirus RV
Pneumococcal conjugate PCV
Influenza (2 doses for some) Flu (2 doses for some)
Measles, mumps, rubella MMR
Varicella Varicella
Hepatitis A Hep A
Meningococcal MenACWY
Pneumococcal polysaccharide PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
DTaP DTaP DTaP DTaP DTaP
IPV IPV IPV IPV
Hib Hib Hib Hib Hib
RV RV RVe
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRf MMR MMR
Varicella Varicella
Hep A (2-dose series) Hep A (2-dose series)
MenACWY
PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
Hib
RV RV RVe
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRf MMR MMR
Varicella Varicella
Hep A (2-dose series) Hep A (2-dose series)
MenACWY
PPSV

Birth
Birth
1
Month
1
Mo.
2
Months
2
Mos.
4
Months
4
Mos.
6
Months
6
Mos.
12
Months
12
Mos.
15
Months
15
Mos.
18
Months
18
Mos.
19-23
Months
19-23
Mos.
2-3
Years
2-3
Yrs.
4-6
Years
4-6
Yrs.
Hep B Hep B Hep B
Hib
RV RV RVe
PCV PCV PCV PCV PCV
Influenza (yearly)
MMRf MMR MMR
Varicella Varicella
Hep A (2-dose series) Hep A (2-dose series)
MenACWY
PPSV

“USE COMBINATION VACCINES
INSTEAD OF SEPARATE INJECTIONS
WHEN APPROPRIATE.”
– Advisory Committee on Immunization Practices, 20213
By using these two combination vaccines as directed,
your office could:

Blue and purple pill bottle icons

Help minimize the
number of injections

Pentacel & Quadracel allow you to use only 2 products across the entire childhood series for DTaP, IPV, and Hib.1-4

Help improve timeliness of vaccination coverage

Combination vaccines may help increase timeliness of vaccination administration and coverage.4,6,7

Doctor icon with check mark
Bar graph icon

Help streamline inventory, billing, and administration prep time4

COMPLETE THE DTaP, IPV, AND Hib SERIES
FROM START TO FINISH
Provide CDC-recommended DTaP, IPV, and Hib immunizations
with Pentacel & Quadracel1-3

Thermometer icon

Most common
adverse reactions

The most common local and systemic adverse reactions to Pentacel include erythema, swelling, and tenderness at the injection site; fever; fussiness; and abnormal crying. The most common local and systemic adverse reactions to Quadracel include pain, erythema, and edema at the injection site; myalgia; malaise; and headache.1,2

One less injection

By using Quadracel, a combination booster dose, you can complete the DTaP and IPV immunization series with one less injection and fewer vaccines to store in your refrigerator compared to single-entity alternatives.2,3

Downward arrow
Bottle icon for 5th dose

Antigen continuity

Using Quadracel, you can have continuity of DTaP and IPV antigens across the 5-dose series1-3,5

Important Safety Information for Pentacel and Quadracel

Contraindications to vaccination with Pentacel or Quadracel vaccine include: a severe allergic reaction (e.g., anaphylaxis) to any ingredient of the vaccine, or following any other diphtheria toxoid-, tetanus toxoid-, pertussis antigen-containing vaccine, inactivated poliovirus vaccine, or Haemophilus influenzae type b vaccine (Pentacel only); encephalopathy within 7 days after a previous dose of a pertussis antigen-containing vaccine with no other identifiable cause; or a progressive neurologic disorder.

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Please see full Prescribing Information for Pentacel (49281-0510-05 and 49281-0511-05).